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KMID : 0380219960290010068
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Journal of Biochemistry and Molecular Biology
1996 Volume.29 No. 1 p.68 ~ p.72
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Increased Expression of c-jun in the Bile Acid-Induced Apoptosis in Mouse F9 Teratocarcinoma Stem Cells
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Baek Jin-Hyen
Kang Chang-Mo
Chung Hae-Young
Park Myung-Hwan
Kim Kyu-Won
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Abstract
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Ursodeoxycholic acid (UDCA) and lithocholic acid (LCA), secondary bile acids, have been shown to have a cell differentiation activity in mouse F9 teratocarcinoma stem cells. Treatment with bile acids induced morphological changes, including cytoplasmic and nuclear membrane blebbing, aggregation of organelles, and chromatin condensation, corresponding to apoptosis. Moreover, the bile acids induced intemucleosomal DNA fragmentation, a hallmark of apoptosis. In addition, the expression of c-jun was increased, but that of c-myc and laminin was decreased during apoptosis induced by the bile acids in F9 cells. These results suggest that the bile acids can induce apoptosis in F9 cells. Furthermore, the c-jun expression may be related to the apoptosis induced by UDCA or LCA in F9 cells.
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KEYWORD
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apoptosis, c-jun, lithocholic acid, mouse F9 teratocarcinoma stem cells, ursodeoxycholic acid
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